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. Author manuscript; available in PMC: 2019 Oct 11.
Published in final edited form as: Obesity (Silver Spring). 2019 Apr 1;27(5):803–812. doi: 10.1002/oby.22440

Figure 5.

Figure 5.

The lack of FXR altered gut microbiota composition (N = 5 per group). (A) Weighted Unifrac analysis of beta diversity. (B) Shannon analysis of microbiome diversity. (C) Phylum Fimicutes in LFD-fed mice. WT-LFD vs. FXRko, p = 0.01. (D) Phylum Bacteroidetes in LFD-fed mice. WT-LFD vs. FXRko-LFD, p = 0.0004. (E) Phylum Proteobacteria in LFD-fed mice. WT-LFD vs. FXRko-LFD, p = 0.002. (F) Phylum Fimicutes in HFD-fed mice. WT-HFD vs. FXRko-HFD, p = 0.1. (G) Phylum Bacteroidetes in HFD-fed mice. WT-HFD vs. FXRko-HFD, p = 0.25. (H) Phylum Proteobacteria in HFD-fed mice. WT-HFD vs. FXRko-HFD, p = 6.5E-07. (I) Phylum Fimicutes in BD-treated mice. WT-BD vs. FXRko-BD, p = 0.05. (J) Phylum Bacteroidetes in BD-treated mice. WT-BD vs. FXRko-BD, p = 0.2. (K) Phylum Proteobacteria in BD-treated mice. WT-BD vs. FXRko-BD, p = 0.004.