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. Author manuscript; available in PMC: 2019 Nov 17.
Published in final edited form as: Lab Invest. 2019 May 17;99(10):1547–1560. doi: 10.1038/s41374-019-0264-3

Figure 2.

Figure 2

Early retinal cellular changes in diabetic Nile rats. Cell number trends of endothelial cells, pericytes and acellular capillaries (A) and pericyte to endothelial cell ratios (B) as diabetes progresses. N = 48 rats from 20 to 44 weeks old C: Micrographs showing evidence of pericyte loss - diabetic retina on the left and age-matched control on the right. E = endothelial cells. P = pericytes. Pericytes have smaller dark-staining nuclei compared to endothelial cells, which have larger nuclei with lighter staining. Orange outline = diabetic retinopathy. Blue outline = control. D: A Venn diagram with the number of diabetic Nile rats having the respective conditions. Diabetic rats were defined as having each of the three conditions by using a cutoff calculated from the average count of the controls plus one standard deviation (n = 11 diabetic rats and 11 control rats).