Skip to main content
. Author manuscript; available in PMC: 2020 Mar 18.
Published in final edited form as: Nature. 2019 Sep 18;574(7777):254–258. doi: 10.1038/s41586-019-1579-3

Figure 2. ILC3-intrinsic Arntl regulates gut homeostasis and defence.

Figure 2

a, Enteric ILC3. n=4. b, Gut T helper cells. n=5. c, Epithelial reactivity genes. n=5 d, Proteobacteria. Arntlfl n=5; ArntlΔRorgt n=6. e, Colon of C. rodentium infected mice. n=5. f, Colitis score. n=5. g, Colon length. n=5. h, Infection burden. Rag1-/-.Arntlfl n=6, Rag1-/-.ArntlΔRorgt n=7. i, Bacterial translocation to the spleen. Rag1-/-.Arntlfl n=6, Rag1-/-.ArntlΔRorgt n=7. j, Survival. n=5; k, Epithelial lipid transporter genes. Arntlfl n=4; ArntlΔRorgt n=5. l, Adipose tissue. n=5. (d) White/Grey: light/dark period. Scale bars: 250μm. Data are representative of at least 3 independent experiments. (a-l) n represents biologically independent animals. Mean and error bars: s.e.m. (a,b,f,g,i,k) two-tailed Mann-Whitney U test; (d) Cosinor analysis; (h) two-way ANOVA and Sidak’s test; (j) Log-rank test; (l) two-tailed unpaired Student t-test. *P<0.05; **P<0.01; ***P<0.001; ns not significant.