Table 1.
Technologies developed by CCNE awardees. The purpose of this table is to give the Reader an overview of the diversity of projects funded in CCNE grants. We were not able to include all projects – it would make the table too exhaustive. Each CCNE is represented with their most unique projects and also those which progressed to more advanced levels of maturity. The references in the table are not necessarily the most recent ones for a particular technology; they represent the status of work during the time the investigator was holding the grant. The last column in the table lists the company(ies) that licensed the technology for future commercialization and the clinical trial(s) number, if they are is being conducted for the technology.
| Technology and Cancer Application | Investigator/Institution | Publications | Clinical Translation Status (companies and trials) |
|---|---|---|---|
| Diagnostics and Imaging | |||
| Microfluidic-based Integrated Blood Barcode diagnostic devices | James Heath Caltech/UCLA |
(Bailey et al., 2007; Fan et al., 2008b) | Integrated Diagnostics (Biodesix) |
| Monitoring and predicting response to cancer therapies and immunotherapy using Single Cell Barcode Chips | James Heath and Antoni Ribas Caltech/UCLA |
(Ma et al., 2013; Zhou et al., 2018) | Integrated Diagnostics (Biodesix), Isoplexis |
| Devices based on giant magneto-resistance and flow magnetic levitation to detect proteins as well as capture and concentrate circulating cancer cells | Shan Wang and Utkan Demirci Stanford University |
(K. Kim et al., 2018; J.-R. Lee, Magee, Gaster, LaBaer, & Wang, 2013; L.-G. Liang et al., 2017) | MagArray, Levitas |
| Nanoparticles for multi-modal imaging in cancer | Sanjiv Sam Gambhir Stanford University |
(X. He, Gao, Gambhir, & Cheng, 2010; Kircher et al., 2012) | ENDRA Life Sciences |
| Tools for transrectal ultrasound and photoacoustic imaging | Sanjiv Sam Gambhir Stanford University |
(Garai et al., 2013; Willmann et al., 2017) | ENDRA Life Sciences NCT02365883 |
| BarCode assays for in vitro cancer diagnosis | Chad Mirkin Northwestern University |
(Alhasan et al., 2012; Taton, Mirkin, & Letsinger, 2000) | Nanosphere (Luminex) |
| Diagnostic μ-NMR devices based on nanoparticle aggregation for detection of proteins, circulating tumor cells, and microvesicles | Ralph Weissleder MIT/Harvard University |
(Ghazani et al., 2014; Hakho Lee et al., 2009) | T2 Biosystems |
| Spherical nucleic acid (SNAs) nanoconstructs for intracellular imaging | Chad Mirkin and Colby Shad Thaxton Northwestern University |
(Halo et al., 2014; Prigodich et al., 2012) | Aurasense (Exicure) |
| Microfluidic-based screening of DNA methylation for early cancer diagnostics and post-therapy monitoring | Jeff Wang, Stephen Baylin, and James Herman Johns Hopkins University |
(Athamanolap, Shin, & Wang, 2014) | |
| Nanocrystals for multiplexed cancer detection in vitro and in vivo | Shuming Nie, Lily Yang, and Gang Bao Emory University/Georgia Tech |
(A. M. Smith, Dave, Nie, True, & Gao, 2006; Xing, Smith, Agrawal, Ruan, & Nie, 2006) | Ocean Nanotech |
| Carbon nanotube (CNT) X-ray systems to develop instrumentation for radiation therapy and diagnostic medical imaging | Otto Zhou UNC Chapel Hill |
(Hadsell et al., 2013; G. Yang et al., 2011) | XinRay Systems, XinVivo, XinNano Materials, Xintek NCT01773850 |
| Intraoperative sentinel lymph node mapping and radiotherapy using C-dot nanoparticles | Michelle Bradbury and Ulrich Wiesner Memorial Sloan Kettering Cancer Center/Cornell University |
(Bradbury et al., 2016; F. Chen et al., 2018) | Elucida Oncology NCT01266096, NCT02106598 |
| Self-assembling and bio-responsive nanoparticles to probe tumor microenvironment | Jianghong Rao Stanford University |
(G. Liang, Ren, & Rao, 2010; Witney et al., 2015) | |
| Tools to monitor immune cell/cancer cell interactions in novel genetically encoded gas nanovesicles | Mikhail Shapiro and Antoni Ribas ISB/CalTech/UCLA |
(G. J. Lu et al., 2018; Shapiro et al., 2014) | |
| Quantum dots and bacteriophage-inspired nanomaterials for detection of tumor spread | Angela Belcher and Moungi Bawendi MIT/Harvard University |
(Cuneo et al., 2013; Ghosh et al., 2012) | Lumicell, Quantum Dot Corporation |
| Bioresponsive probes for tumor imaging | Martin Pomper Johns Hopkins University |
(Bhang, Gabrielson, Laterra, Fisher, & Pomper, 2011) | Molecular Insight Pharmaceuticals (Progrenics) |
| Novel nanoparticle agents for molecular imaging of cancer | Thomas Meade and Gayle Woloschak Northwestern University |
(Endres, Paunesku, Vogt, Meade, & Woloschak, 2007) | |
| Microfluidic systems for synthesis of PET probes | Hsian-Rong Tseng and Michael Phelps CalTech/UCLA |
(Yanju Wang et al., 2009) | Sofie Biosciences |
| Therapeutics | |||
| Development and translation of targeted polymeric docetaxel nanoparticle therapies for solid tumors | Omid Farokhzad and Robert Langer MIT/Harvard University |
(Behzadi et al., 2017; Farokhzad et al., 2006) | BIND Therapeutics (Pfizer), Blend Therapeutics (Tarveda Therapeutics) Several trials – Table 4 |
| Development and translation of cyclodextrin-containing polymer conjugates of chemotherapeutics and RNAi | Mark Davis CalTech/UCLA |
(Davis, 2009; Davis et al., 2010) | Cerulean Pharma (NewLink Genetics), Several trials – Table 4 Calando Pharmaceuticals NCT00689065 |
| Strategies for crossing physiological barrier using nanoparticles | Mark Davis CalTech/UCLA |
(Clark & Davis, 2015) | |
| PRINT™ nanoparticles for chemotherapy, siRNA, and vaccine delivery | Joseph DeSimone UNC Chapel Hill |
(Mueller, Tian, & DeSimone, 2015; Perry, Herlihy, Napier, & Desimone, 2011) | Liquidia |
| Spherical nucleic acid (SNAs) for gene therapy and design of nanostructure vaccines | Alexander Stegh, Andrew Lee, and Chad Mirkin Northwestern University |
(Jensen et al., 2013; Skakuj et al., 2018; Yue et al., 2018) |
NCT03020017 Exicure, NCT03086278 NCT03684785 |
| Targeted and tumor-penetrating siRNA nanocomplexes for treatment of ovarian cancer | Sangeeta Bhatia and Phillip Sharp MIT/Harvard University |
(Ren et al., 2012) | Alnylam Pharmaceuticals |
| A comprehensive treatment of multiple myeloma through nanoparticle-based tumor microenvironment targeting | Kareem Azab, John DiPersio, and Gregory Lanza Washington University |
(Azab et al., 2012; de la Puente et al., 2018) | Cellatrix, Targeted Therapeutics |
| Deep tissue PDT enabled through the Cerenkov radiation induced therapy (CRIT) | Samuel Achilefu Washington University |
(Kotagiri, Sudlow, Akers, & Achilefu, 2015) | |
| Mucus penetrating nanoparticles for small cell lung cancer | Justin Hanes, Charles Rudin, and Craig Peacock Johns Hopkins University |
(Nance et al., 2012) | Kala Pharmaceuticals |
| Multi-stage nanoparticle vectors for cancer therapeutics | Mauro Ferrari, Paolo Decuzzi, and Gabriel Lopez-Berestein UT/MD Anderson Cancer Center |
(Martinez et al., 2013; Yokoi et al., 2013) | Leonardo Biosystems |
| Mining TCGA data to identify targets for nanotherapies | Anil Sood and Gabriel Lopez-Berestein UT/MD Anderson Cancer Center |
(Shen et al., 2013) | NCT01591356 |
|
Nano-assemblies for ligand-directed imaging and therapy of solid tumors |
Wadih Arap and Renata Pasqualini UT / MD Anderson Cancer Center |
(Hosoya et al., 2016; T. L. Smith et al., 2016) | PhageNova Bio |
| Nanoparticle strategies for siRNA and vaccine delivery | Leaf Huang UNC Chapel Hill |
(Yuhua Wang et al., 2013; Xu et al., 2013) | Qualiber, Inc. |
| Nanoparticle strategies for siRNA and vaccine delivery | Leaf Huang UNC Chapel Hill |
(Yuhua Wang et al., 2013; Xu et al., 2013) | Qualiber, Inc. |
| Nanoparticles for hyperthermia of ovarian and breast cancers | Ian Baker and Jack Hoopes Dartmouth College |
(Stigliano et al., 2013) | |
| Combination therapies to overcome multi-drug resistance (MDR) in cancer | Vladimir Torchilin and Tamara Minko Northeastern University |
(Salzano et al., 2015) | Nemucore Medical Innovations |
| Tumor homing peptide-nanoparticle complexes | Erkki Ruoslahti Sanford Burnham Prebys |
(Sharma et al., 2017; Sugahara et al., 2009) | DrugCendR |
| Nanoparticle strategies for targeting tumor microenvironment | Roger Tsien UC San Diego |
(Crisp et al., 2014) | |
| Silicon oxide porous particles for drug delivery | Michael Sailor and Sadik Esener UC San Diego |
(Anglin, Cheng, Freeman, & Sailor, 2008; Gu, Park, Duong, Ruoslahti, & Sailor, 2010) | Genoptix |
| Targeting angiogenesis using nanoparticle-based imaging and therapy | Gregory Lanza and Samuel Wickline Washington University |
(Winter et al., 2003, 2008) | Kereos |
| Nanoparticles for combination of radio- and immunotherapy | Andrew Wang UNC Chapel Hill |
(Min et al., 2017) | |
| Tools to study cancer biology | |||
| Nanostructured matrices for cancer cell biology interrogations | Milan Mrksich and Bartosz Grzybowski Northwestern University |
(Kandere-Grzybowska et al., 2010; O’Kane & Mrksich, 2017) | SAMDI Tech, Grzybowski Sc. Inventions |
| Nanotechnologies for genome, protein secretion, and biophysical analyses at single cell level | Steve Quake, Luke Lee, and Scott Manalis Stanford University/MIT |
(Bryan et al., 2014; Jianbin Wang, Fan, Behr, & Quake, 2012) | Fluidigm, Travera |
| In vivo spectroscopic quantification of ligand-nanoparticle binding | Brian Pogue and Steven Fiering Dartmouth College |
(Sexton et al., 2013) | |