Table 2.

Potential therapeutic targets discovered in preclinical studies for treating ESR1 mutant-bearing tumors.

Target Name	Targeted Therapy	Reference
CDK7	THZ1	Harrod et al, 201721; Jeselsohn et al, 201820
BET family	JQ1	Ladd et al, 201669
Class I and II HDAC	Vorinostat	Ladd et al, 201669
SRC-3	SI-2	Gates et al, 201818
CDK2	Dinaciclib	Scott et al, 201770
IGF-1R	OSI-906	Gelsomino et al, 201614; Li et al, 201824
UPR	BHPI	Mao et al, 201671
Notch	RO4929097	Gelsomino et al, 201872