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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Jun 26;11(6):e1571. doi: 10.1002/wnan.1571

Figure 5. Strong static fields containing field-free regions can be used to target alternating magnetic fields for magnetic heating and drug release.

Figure 5.

(a) In the low-field region, magnetic nanoparticles respond to the applied AMF to generate heat. Outside of the field-free region, the nanoparticles are “pinned” in the direction of the static field, preventing their response to the AMF and thereby suppressing heating. (b) Static fields containing field-free regions have been used for high-resolution magnetic particle imaging and targeted tissue ablation via magnetic hyperthermia. From Tay et al. (2018). (c) By adding a third magnet, it is possible to independently control the size and location of the field-free targeting region. From J. F. Liu et al. (2018).