Skip to main content
. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: J Neurochem. 2019 Jul 28;151(1):50–63. doi: 10.1111/jnc.14813

Figure 6. Oral administration of aspirin upregulates SOCS3 in vivo in cortical microglia of 5XFAD mice via PPARα.

Figure 6.

A) Six-month old 5XFAD and 5XFAD/PPARα (−/−) mice (n=6 per group) were treated with aspirin (2 mg/kg body wt/d) via gavage for 30 d followed by double-labeling of cortical sections for SOCS3 and Iba1. GFAP positive (B) and Iba1 positive (C) cells were counted in one section (two images per section) of each of six mice per group. *p < 0.05 vs non-Tg for GFAP; **p < 0.01 vs non-Tg for Iba1. However, a two-way ANOVA with treatment and genotype did not show any significance for either GFAP-positive or Iba1-positive cells across the group since there was not much difference of either GFAP-ir or Iba1-ir cells among 5XFAD, 5XFAD + aspirin, 5XFAD/PPARα (−/−), and 5XFAD/PPARα (−/−) + aspirin-treated groups.