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. Author manuscript; available in PMC: 2020 Oct 11.
Published before final editing as: Matrix Biol. 2019 Apr 11:S0945-053X(18)30483-9. doi: 10.1016/j.matbio.2019.04.001

Figure 3: Comparison of non-myocyte populations, mesenchymal stem cells (MSC) and cardiac fibroblasts (cFB), in Biowire II platform.

Figure 3:

A) HES3 ESC derived atrial tissues compacted during the first week of culture. (n⩾10) B) Atrial specific electrical conditioning protocol. C) Tissue appearance at the endpoint of culture after electrical conditioning. D) Force-frequency relationship (FFR) (n⩾15). E) Excitation threshold (ET) and F) Maximum capture rate (MCR) were significantly improved after electrical conditioning in both groups. (n⩾10) G) Action potential profiles, H) action potential duration, I) action potential amplitude, J) minimum diastolic potential and K) upstroke velocity were compared between the tissues with the two cell types. For electrophysiological assessment, the AP parameters were multiple pokes from at least three tissues. Data presented as mean ± stdev, Student’s t-test or Mann-Whitney test or ANOVA on ranks with Dunn’s multiple comparisons test.