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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Biol Psychiatry. 2019 May 13;86(9):682–692. doi: 10.1016/j.biopsych.2019.04.035

Figure 8.

Figure 8.

Experience-dependent modulation of SSTIN-mediated inhibition of IL-mPFC layer 5 pyramidal neurons. A) Schematic presentation of light-evoked IPSC recording in the IL-mPFC layer 5 pyramidal neurons of SST-ChR2 mice. B) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of pre-adolescent tone alone (13 neurons/5 mice), fear conditioning (14 neurons/5 mice), and fear extinction groups (15 neurons/5 mice) (F (2, 39) = 1.14, p = 0.33; TA vs FC: p = 0.57; TA vs FE: p = 0.6; FC vs FE: p = 1). C) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of adolescent tone alone (18 neurons/6 mice), fear conditioning (15 neurons/5 mice), and fear extinction groups (18 neurons/5 mice) (F (2, 48) = 7.8, p = 0.001; TA vs FC: p = 0.003; TA vs FE: p = 0.006; FC vs FE: p = 1). D) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of adult tone alone (15 neurons/6 mice), fear conditioning (15 neurons/5 mice), and fear extinction groups (18 neurons/5 mice) (F (2, 45) = 1.05, p = 0.36; TA vs FC: p = 0.49; TA vs FE: p = 1; FC vs FE: p = 1). Comparison of IPSC amplitude in pre-adolescent, adolescent and adult TA groups: (F (2, 43) = 4.45, p = 0.017; pre-adolescent vs adolescent: p = 0.071; pre-adolescent vs adult: p = 1; adolescent vs adult: p < 0.031). Upper panels show example traces. Scale: 20 ms/200 pA.