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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Gynecol Oncol. 2019 Aug 14;155(1):51–57. doi: 10.1016/j.ygyno.2019.08.006

Table 1:

Clinical characteristics of the cohort (N=79)

Variables N=79
Age at Diagnosis, Median (Mean), range 57 (55.9), 24–72

Histology
 High-grade serous 68 (86%)
 Other* 11 (14%)

Stage at diagnosis
 I/II 3 (4%)
 III 45 (57%)
 IV 31 (39%)

BRCA 1/2 Mutations (germline or somatic)
 Wildtype 52 (66%)
BRCA-mutated 21 (27%)
 Not tested 6 (7%)

Optimal debulking (25 missing)
 No 10 (18%)
 Yes 44 (82%)

Primary chemo treatment (12 missing)
 Neoadjuvant 26 (39%)
 Adjuvant 41 (61%)

Platinum status at ICI initiation
 Sensitive 13 (16%)
 Resistant/Refractory 66 (84%)

ICI target
 PD-1/PD-L1 35 (44%)
 PD-1/PD-L1+CTLA-4 27 (34%)
 PD-1/PD-L1+Other 12 (16%)
 Other 5 (6%)

CA-125, Median(Mean), range 158 (618.5), 9–7087

BMI, Median(Mean), range 25.9 (27.2), 18.5–50.2

ICI duration in months, Median (Mean), range 2.8 (3.9), 0.6–13.8
 Long ICI (ICI duration ≥24 weeks) 16 (20%)
 Short ICI (ICI duration <24 weeks) 63 (80%)

Months lag from Dx to ICI, Median(Mean), range 39.7 (45.9), 10.1–205.9

Treatment Lines
Pre-ICI (8 missing), Median (Mean), range 4 (4.1), 1–12
Post-ICI Median (Mean), range 2 (2.9), 1–8
Total (8 missing), Median(Mean), range 7 (8.1), 4–16

ICI, immune checkpoint inhibitor; PD-1, programmed cell death protein 1; PD-L1, programmed death-ligand 1; CTLA-4, cytotoxic T-Lymphocyte associated protein 4; dx, diagnosis

*

Other histologies: clear cell carcinoma (n=5), endometrioid carcinoma (n=2), low grade serous (n=2), mixed serous and endometrioid (n=1), or adenocarcinoma not otherwise specified (NOS) (n=1)