Table 1:
Variables | N=79 |
---|---|
Age at Diagnosis, Median (Mean), range | 57 (55.9), 24–72 |
Histology | |
High-grade serous | 68 (86%) |
Other* | 11 (14%) |
Stage at diagnosis | |
I/II | 3 (4%) |
III | 45 (57%) |
IV | 31 (39%) |
BRCA 1/2 Mutations (germline or somatic) | |
Wildtype | 52 (66%) |
BRCA-mutated | 21 (27%) |
Not tested | 6 (7%) |
Optimal debulking (25 missing) | |
No | 10 (18%) |
Yes | 44 (82%) |
Primary chemo treatment (12 missing) | |
Neoadjuvant | 26 (39%) |
Adjuvant | 41 (61%) |
Platinum status at ICI initiation | |
Sensitive | 13 (16%) |
Resistant/Refractory | 66 (84%) |
ICI target | |
PD-1/PD-L1 | 35 (44%) |
PD-1/PD-L1+CTLA-4 | 27 (34%) |
PD-1/PD-L1+Other | 12 (16%) |
Other | 5 (6%) |
CA-125, Median(Mean), range | 158 (618.5), 9–7087 |
BMI, Median(Mean), range | 25.9 (27.2), 18.5–50.2 |
ICI duration in months, Median (Mean), range | 2.8 (3.9), 0.6–13.8 |
Long ICI (ICI duration ≥24 weeks) | 16 (20%) |
Short ICI (ICI duration <24 weeks) | 63 (80%) |
Months lag from Dx to ICI, Median(Mean), range | 39.7 (45.9), 10.1–205.9 |
Treatment Lines | |
Pre-ICI (8 missing), Median (Mean), range | 4 (4.1), 1–12 |
Post-ICI Median (Mean), range | 2 (2.9), 1–8 |
Total (8 missing), Median(Mean), range | 7 (8.1), 4–16 |
ICI, immune checkpoint inhibitor; PD-1, programmed cell death protein 1; PD-L1, programmed death-ligand 1; CTLA-4, cytotoxic T-Lymphocyte associated protein 4; dx, diagnosis
Other histologies: clear cell carcinoma (n=5), endometrioid carcinoma (n=2), low grade serous (n=2), mixed serous and endometrioid (n=1), or adenocarcinoma not otherwise specified (NOS) (n=1)