Table 2.
Odds of oncologic and clinical outcomes in patients with intrahepatic cholangiocarcinoma who underwent resection at academic centers (vs community centers) and high-volume centers (vs low-volume centers), based on multivariable analysis*.
| FACILITY TYPE | FACILITY VOLUME | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Outcomes | Community Center | Academic Center | Unadjusted P-value | OR (95% CI) | Adjusted P-value | Low-Volume Center | High-Volume Center | Unadjusted P-value | OR (95% CI) | Adjusted P-value |
| Positive surgical margins | 105 (26.1%) | 370 (21.4%) | 0.04 | 0.71 (0.51-0.98) | 0.04 | 238 (23.0%) | 216 (21.9%) | 0.57 | 0.87 (0.64-1.19) | 0.39 |
| Lymph nodes examined ≥6 | 33 (8.0%) | 230 (12.6%) | 0.01 | 1.28 (0.75-2.16) | 0.37 | 113 (10.6%) | 140 (13.4%) | 0.050 | 1.17 (0.72-1.91) | 0.53 |
| Length of stay ≥7 days | 234 (55.3%) | 1,056 (57.6%) | 0.39 | 1.12 (0.82-1.55) | 0.47 | 607 (55.9%) | 608 (57.6%) | 0.43 | 1.06 (0.76-1.47) | 0.73 |
| Readmission within 30 days | 30 (7.1%) | 154 (8.5%) | 0.36 | 0.82 (0.44-1.52) | 0.53 | 76 (7.1%) | 99 (9.4%) | 0.052 | 1.39 (0.73-2.65) | 0.32 |
| Adjuvant chemotherapy administered | 112 (27.8%) | 530 (30.6%) | 0.28 | 1.26 (0.91-1.74) | 0.17 | 315 (29.9%) | 325 (31.1%) | 0.57 | 1.14 (0.84-1.55) | 0.39 |
| 30-day mortality | 26 (7.5%) | 62 (4.0%) | 0.01 | 0.60 (0.34-1.07) | 0.09 | 52 (5.9%) | 33 (3.6%) | 0.02 | 0.68 (0.40-1.16) | 0.16 |
| 90-day mortality | 44 (12.8%) | 123 (8.0%) | 0.004 | 0.62 (0.39-0.97) | 0.03 | 92 (10.5%) | 70 (7.7%) | 0.04 | 0.68 (0.46-1.01) | 0.06 |
| 1 year overall survival^ | 71.5% | 81.1% | 0.01 | 0.78~ (0.63-0.96) | 0.02^ | 76.8% | 81.7% | 0.32 | 0.95~ (0.79-1.14) | 0.59^ |
Multilevel logistic mixed-effects model adjusted for Commission on Cancer (CoC) facility type or facility volume, age, sex, race, Charlson score, clinical stage, tumor size, tumor grade, insurance type, and distance from patient’s zip code to hospital zip code.
Multilevel mixed-effects parametric survival-time model adjusted for CoC facility type or facility volume, age, sex, race, Charlson score, clinical stage, tumor size, tumor grade, insurance type, distance from patient’s zip code to hospital zip code, margin status, and receipt of adjuvant chemotherapy.
Hazard ratio
OR, odds ratio; CI, confidence interval