Illustrations of the anterior circulation vessel wall analysis for a subject. From left to right, after defining the start and ending points, the intracranial internal carotid artery and middle cerebral artery are centerline tracked and straightened. The sliced images are then processed with the proposed segmentation and used to calculate NWI. Three interested locations in the vessel, as marked by yellow arrows, could be further checked for the NWI values, cross-sectional slices and their corresponding segmentations.