Figure 2.

Changes in eGFR (ml/min per 1.73 m²) over time expressed as mean ± SE at three time points: DCCT, EDIC and outcome visits. DCCT visit was at year 1 for cases and controls whereas the EDIC visit was at year 18 and year 16 for cases and controls, respectively, (see Table 1 for range and results for further description). Matching of controls with cases was done at the outcome visit when eGFR had fallen below 60 mL/min per 1.73 m² in cases but not in controls. Therefore, at the outcome visit eGFR was markedly different by study design. By Tukey's multiple comparisons post hoc there was a significant decline in both cases and controls from the DCCT to the EDIC visit (adjusted P < 0.0001).