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. 2019 Oct 11;9:14669. doi: 10.1038/s41598-019-51183-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ZINC40099027 promotes the healing of indomethacin-induced small intestine injury in mice and does not affect murine kidney and liver morphology. (a) Typical macroscopic small intestinal ulcerative lesions induced by a single administration of indomethacin at a dose of 15 mg/kg subcutaneously at 24 hours after administration. (b) Hematoxylin and eosin staining of a typical indomethacin-induced small intestinal ulcer at day 4. (c) Representative images of ulcers from DMSO-treated mice and ZINC40099027-treated mice at day 4 suggest that ZINC40099027-treated mice have smaller ulcer areas than mice treated with only the DMSO vehicle. (d) Quantitation of total small intestinal ulcer area in DMSO-treated mice and ZINC40099027-treated mice demonstrates that ZINC40099027 reduces the total ulcer area after 3 days of intraperitoneal injection every 6 hours, (n = 22 in DMSO, n = 25 in ZINC40099027, *p < 0.05). (e) There is no obvious difference in renal or (f) liver morphology between typical hematoxylin and eosin stains of kidneys from mice treated with DMSO or ZINC40099027 for three days beginning one day after ulcer induction by subcutaneous injection of 15 mg/kg indomethacin, (50× magnification kidney, 100× magnification liver).