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. 2019 Oct 11;2:375. doi: 10.1038/s42003-019-0601-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Snap29 mutant female mice exhibit gait defects as measured by Catwalk. Catwalk assay was used to monitor gait parameters in Snap29^+/+, Snap29^+/⁻, and Snap29^−/− females. The run characteristic parameter run average was significantly slower in Snap29^−/− females (a). The temporal parameter initial dual stance was significantly elevated in both front paws (b). The spatial parameter print length was increased in both right and left front paws (c). The kinetic parameter swing speed was decreased in all paws of mutant animals (d). The interlimb coordination parameter support on two paws was significantly reduced in Snap29^−/− females (e). The grip strength was assessed for fore limbs (f) and hind limbs (g). Snap29^−/− females exhibited weaker fore and hind limbs than Snap29^+/+ animals. RF right front paw; RH right hind paw; LF left front paw, and LH left hind paw. RF and LF are in black and RH and LH are in gray. Statistical significance: *p < 0.05, **p < 0.01, and ***p < 0.001. Error bars represent standard error of the Mean