Fig. 6.

RORγ inhibitors alone or with statins cause tumor regression and block metastasis. a Mice bearing PDX-1079 were treated, p.o., 5 times per week, with vehicle or 50 mg/kg XY018 for 57 days. Tumor volume and representative images are shown. n = 7 mice per group. Student’s t test. ^∗∗p < 0.01. mpk, mg/kg. b K–M survival plot of 4T1 tumor-bearing mice treated with vehicle or XY018 (20 mg/kg, i.p.) for 56 days, n = 10. c Lung tumor nodules metastasized from primary sites were analyzed for 4T1 tumor-carrying mice treated with XY018 (20 mg/kg, i.p.) or vehicle daily for 4 weeks. Representative lung section images were taken with arrows indicating tumor nodules. n = 6. Student’s t test. ^∗∗p < 0.01. d, e PDX-1079 and PDX-1173 were treated, 5 times per week, p.o., with vehicle, 20 mg/kg XY018 alone, 15 mg/kg ATV alone, or both XY018 + ATV for indicated days. Volumes (left) and weights (right) are shown. n = 7. Student’s t test. ^∗∗p < 0.01. f PDX-1079 was treated, 5 times per week, p.o., with vehicle, 20 mg/kg XY018 alone, 15 mg/kg simvastatin alone (SIM), or both XY018 + SIM for 47 days. Volumes are shown. n = 7. Student’s t test. ^∗∗p < 0.01. g Mice bearing MDA-MB468 were treated, 5 times per week, p.o., with vehicle, 20 mg/kg XY018 alone, 15 mg/kg ATV alone, or both XY018 + ATV for 32 days. Volumes are shown. n = 7. Student’s t test. ^∗∗p < 0.01