Figure 1.

CD40^fl/flCD11c^cre mice on HFD are more obese than WT mice. (A) Body weight gain during 18 weeks of standard (SFD) or high fat diet (HFD) feeding. (B) epidydimal adipose tissue (EpAT) tissue weight after 18 weeks of diet. (C) EpAT adipocyte size after 18 weeks of diet and representative HE pictures of EpAT of CD40^fl/flCD11c^cre mice and WT mice fed an HFD (scale bar is 100 µm). (D) Total plasma cholesterol and lipid fractions. (E) Plasma triglycerides. (F) Plasma leptin and adiponectin levels. Data is represented as mean ± SEM. *P < 0.05; **P < 0.01 for comparison between WT and CD40^fl/flCD11c^cre mice fed the same diet. n = 7/group for SFD, and n = 8/group for HFD.