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. 2019 Oct 11;9:14702. doi: 10.1038/s41598-019-50976-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced numbers of regulatory T cells (Tregs) were found in CD40^fl/flCD11c^cre mice after 18 weeks of HFD. (A) Histological quantification of CD45 staining of liver. (B) Flow cytometric analysis of leukocyte subsets in the liver. (C) % of CD4⁺FoxP3⁺ Tregs in liver. (D) Systemic % of CD4⁺FoxP3⁺ Tregs measured in blood, spleen, and lymph nodes (LN). (E) liver mRNA expression of RORγT and IL-17. (F) mRNA expression of cholesterol metabolism genes in the liver of HFD fed CD40^fl/flCD11c^cre and WT mice. Data is represented as mean ± SEM. *P < 0.05; **P < 0.01, ***p < 0.001 for comparison between WT and CD40^fl/flCD11c^cre mice fed the same diet. n = 7/group for SFD, and n = 8/group for HFD.