Fig. 7.

rhMG53 protects against eccentric-contraction-induced acute and chronic muscle injury in mice. a Time-dependent effects of rhMG53 in protection against eccentric-contraction-induced acute muscle injury in mice. rhMG53 (2 mg/kg, i.v.) was administered at different times after muscle injury. b Dose-dependent effect of rhMG53 in protection against eccentric-contraction-induced acute muscle injury in mice. Various doses of rhMG53 were administered at 4 h post muscle injury. c 24 h after eccentric-contraction-induced muscle injury, rhMG53 (6 mg/kg) was administered subcutaneously. Mice were treated on a daily basis for 28 days. d Area under the curve (AUC) shows significant beneficial effects of rhMG53 in facilitation of recovery of contractile function after eccentric-contraction-induced muscle injury (p < 0.001, compared with saline control). e Blood glucose and triglyceride measurement did not show significant changes after 28 doses of 6 mg/kg (s.c., daily) in mice. Error bar represents the standard deviation and p value was generated by t test