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. 2019 Oct 11;9:14677. doi: 10.1038/s41598-019-50988-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of Rarα inactivation on adrenal steroidogenesis. (A) Expression of aldosterone synthase and 11β-hydroxylase in 12 weeks old male and female Rarα^+/+ and Rarα^−/− mice. (B–F) Expression of steroidogenic genes in male and female Rarα^+/+ and Rarα^−/− mice. mRNA expression of Star (B), Cyp11a1 (C), Cyp11b1 (D) and Cyp11b2 (E) was assessed by RT-qPCR. RT-qPCR were performed on mRNA extracted from 6–11 adrenals from 12 weeks old male and female Rarα^+/+ and Rarα^−/− mice. (F,G) Measure of plasma aldosterone (F) and corticosterone (G) concentration by mass spectrometry in male mice. (H,I) Plasma renin concentration (PRC) (H) and aldosterone to renin ratio (I). Measure of plasma aldosterone, plasma corticosterone and plasma renin were done on 5–6 animals per group. Values are presented as the mean ± SEM; p values were calculated using a Mann-Whitney test or t-test. For correlation, Pearson calculations were performed. *p < 0.05; **p < 0.01.