Table 2.
Expression of enzymes responsible for retinoic acid biosynthesis in control adrenals (n = 11) and in APA (n = 48).
| Gene name | Control adrenal | APA | p |
|---|---|---|---|
| Retinol Binding Protein 1 | 56.16 ± 7.30 | 81.77 ± 6.934 | 0.0673 |
| Stimulated by Retinoic Acid 6 | 1.11 ± 0.13 | 1.485 ± 0.1561 | 0.3187 |
| Retinol Dehydrogenase 5 | 1.05 ± 0.22 | 0.8240 ± 0.0730 | 0.2858 |
| Retinol Dehydrogenase 11 | 19.30 ± 2.21 | 22.07 ± 1.466 | 0.2179 |
| Retinol Dehydrogenase 12 (probe 2) | 1.81 ± 0.35 | 5.704 ± 2.323 | 0.6776 |
| Retinol Dehydrogenase 14 | 2.54 ± 0.32 | 3.914 ± 0.2692 | 0.0058 |
| Aldehyde dehydrogenase 1 Family Member A1 | 24.28 ± 2.63 | 22.47 ± 2.589 | 0.3540 |
| Aldehyde dehydrogenase 1 Family Member A3 | 2.72 ± 0.33 | 1.098 ± 0,1432 | <0.0001 |
| Cytochrome P450 Family 26 Subfamily B Member 1 | 1.69±0.37 | 0.8811 ± 0.1179 | 0.0189 |
| Cellular Retinoic Acid Binding Protein 2 | 1.04 ± 0.31 | 1.076 ± 0.0825 | 0.2858 |
Data are presented as mean ± SEM and are compared with the Mann-Whitney test or t-test (p significant if <0.05). Data are expressed as log2.