Table 3.

Clinical characteristics of 12 and 52 weeks male and female Rarα^+/+ and Rarα^−/− mice.

	Male
	12 weeks			52 weeks
	Rarα +/+	Rarα −/−	p	Rarα +/+	Rarα −/−	p
Total body weight (g)	28.12±0,59	26.45±0,70	0.0135	40.87±1.31	31.53±0.94	<0.0001
Left adrenal weight/total body weight (x1000)	1.531±0.112	1.678±0.144	0.7584	1.135±0.507	1.458±0.817	0.2736
Right adrenal weight/total body weight (x1000)	1.362±0.099	1.161±0.137	0.1112	1.173±0.684	1.460±0.687	0.1354
Left adrenal size (mm)	N.D.	N.D.		2.130±0.124	2.080±0.073	0.6663
Right adrenal size (mm)	N.D.	N.D.		2.015±0.068	2.069±0.066	0.7756
	Female
Total body weight (g)	20.49±0.45	19.48±0.55	0.1612	29.97±1.75	23.25±0.71	0.0005
Left adrenal weight/total body weight (x1000)	2.044±0.091	2.474±0.188	0.0332	1.912±0.164	1.991±0.130	0.7108
Right adrenal weight/total body weight (x1000)	1.623±0.097	2.116±0.126	0.0036	1.506±0.105	1.784±0.162	0.1598
Left adrenal size (mm)	N.D.	N.D.		2.568±0.173	2.463±0.085	0.6095
Right adrenal size (mm)	N.D.	N.D.		2.430±0.156	2.260±0.132	0.3524

N.D., Not Determined. Quantitative data reported as mean ± SEM and compared with the Mann-Whitney test (p significant if <0.05).