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. 2019 Oct 11;9:14685. doi: 10.1038/s41598-019-51102-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Protein alignment of the HsdS specificity unit of the Type I NgoAV Restriction-Modification system (RMS). The three main regions of variation within the unit are shown as a premature stop codon in position 62 of the protein that causes inactivation of the RMS, a variable number of LEAT repeats and a downstream stop codon in position 201 (caused by a change in the length of a poly-G homopolymer) which, in combination, are related to a different recognition motif. The strains with a full-length protein are labelled in green (left), and the methylated motifs detected using PacBio are shown in different colours on the right. ‘−‘ represents gaps and ‘*’ stop codons.