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. 2019 Oct 15;30(22):2814–2826. doi: 10.1091/mbc.E19-07-0364

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© 2019 Haribowo et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 1: — Elevated levels of DoxSL are toxic to yeast. (A) Schematic effect of HSAN IA/C mutations on the substrate promiscuity of SPT. The blue circles highlight the hydroxyl group that is missing in DoxSL. (B–D) Effect of sphingoid bases on the growth of the indicated strains evaluated by a spot assay. Sa, sphinganine; DoxSa, 1-deoxysphinganine; DoxmetSa, 1-deoxymethylsphinganine; DoxSB, 1-deoxysphingoid base; FA-CoA, fatty acyl-CoA; DHCer, dihydroceramide; DoxDHCer, 1-deoxydihydroceramide; DoxmetDHCer, 1-deoxymethyldihydroceramide; DoxCer, 1-deoxyceramide.