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Dehydrocostus lactone prevented ox-LDL-induced secretion of high mobility group box-1 protein (HMGB1) in human aortic endothelial cells (HAECs). Cells were treated with ox-LDL (10 μg/ml) with or without dehydrocostus lactone (DHL) at concentrations of 15 and 30 μM for 24 h. Secretions of HMGB-1 was measured by ELISA (*, #, $, P < 0.01 vs previous group, n = 6).
