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. 2019 Sep 15;11(9):6232–6248.

Figure 4.

Figure 4

Time courses of circulatory levels of inflammatory biomarkers prior to and after acute ICH. A. By day 0, analytical result of circulating level of tumor necrosis factor (TNF)-α, P>0.5. B. By day 0, analytical result of circulating level of interleukin (IL)-6, P>0.5. C. By day 0, analytical result of circulating level of myeloperoxidase (MPO), P>0.5. D. By day 1, analytical result of circulating level of TNF-α, * vs. other groups with different symbols (†, ‡), P<0.0001. E. By day 1, analytical result of circulating level of IL-6, * vs. other groups with different symbols (†, ‡), P<0.0001. F. By day 1, analytical result of circulating level of MPO, * vs. †, P<0.0001. G. By day 3, analytical result of circulating level of TNF-α, * vs. other groups with different symbols (†, ‡, §), P<0.0001. H. By day 3, analytical result of circulating level of IL-6, * vs. other groups with different symbols (†, ‡, §), P<0.0001. I. By day 3, analytical result of circulating level of MPO, * vs. other groups with different symbols (†, ‡, §), P<0.0001. J. By day 7, analytical result of circulating level of TNF-α, * vs. other groups with different symbols (†, ‡, §), P<0.0001. K. By day 7, analytical result of circulating level of IL-6, * vs. other groups with different symbols (†, ‡, §), P<0.0001. L. By day 7, analytical result of circulating level of MPO, * vs. other groups with different symbols (†, ‡, §), P<0.0001. M. By day 14, analytical result of circulating level of TNF-α, * vs. other groups with different symbols (†, ‡, §), P<0.0001. N. By day 14, analytical result of circulating level of IL-6, * vs. other groups with different symbols (†, ‡, §), P<0.0001. O. By day 14, analytical result of circulating level of MPO, * vs. other groups with different symbols (†, ‡, §), P<0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡, §) indicate significance (at 0.05 level). SC = sham-operated control; ICH = intracranial hemorrhage; HA = hyaluronic acid; ICH = intracranial hemorrhage; iPSC-MSC = induced pluripotent stem cell-derived mesenchymal stem cell.