Protein expressions of cell-stress response signaling in LV myocardium by day 5 after IR procedure. A. Protein expression of Phosphoinositide 3-kinase (PI3K), * vs. other groups with different symbols (†, ‡, §), P<0.0001. B. Protein expression of phosphorylated (p)-Akt, * vs. other groups with different symbols (†, ‡, §), P<0.0001. C. Protein expression of glycogen synthase kinase 3β (GSK3β), * vs. other groups with different symbols (†, ‡, §), P<0.0001. D. Protein expression of p-m-TOR, * vs. other groups with different symbols (†, ‡, §), P<0.0001. E. Protein expression of p-AMP-activated protein kinase (AMKP), * vs. other groups with different symbols (†, ‡, §), P<0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n=6 for each group). Symbols (*, †, ‡, §) indicate significance (at 0.05 level). SC = sham-operated control; IR = ischemia reperfusion; CW = cold water; Exo = adipose-derived mesenchymal stem cell-derived exosome.