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The theoretical regulation of bevacizumab on claudin5 signaling pathway. Low-dose bevacizumab up-regulates the expression of P-PI3K, which up-regulates P-JNK and claudin5, so that maintain the integrity of tight junction protein that reduces permeation of vascular ECs. While high-dose bevacizumab up-regulates TGFβ1, then down-regulates claudin5, which increases the permeation of vascular ECs.
