Table 1.

Comparison among major appetite control systems in mice and human obesity.

	Mouse	Human	Observation
Leptin	Genetic deficiency of leptin or its receptor causes hyperphagy and obesity.	High in obesity Low in anorexia nervosa	Paradoxical association of human hyperphagy with high levels of an anorexigenic factor.
Ghrelin	Administration of ghrelin causes hy-perphagy and obesity.	Low in obesity High in anorexia nervosa	Paradoxical association of human hyperphagy with low levels of an orexigenic factor.
ACBP/DBI	ACBP/DBI administration causes hy-perphagy and obesity, while neutrali-zation of ACBP/DBI is anorexigenic.	High in obesity Low in anorexia nervosa	Concordant association of human hyperphagy with high levels of an orexigenic factor.