Table 2.
Associations between independent variables and presentation delay on univariate and multivariate Cox’s regression analysis.
| Observations | Median Delay (days) | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|---|
| Crude HR | 95% CI | P-Value | Adjusted HR | 95% CI | P-Value | |||
| Sex | ||||||||
| Female | 305 | 28 | 1.06 | 0.91–1.23 | 0.47 | |||
| Male | 398 | 30 | Reference | |||||
| Age group | ||||||||
| <15 years | 77 | 21 | 1.31 | 1.02–1.67 | 0.03 | 1.35 | 1.04–1.73 | 0.02 |
| 15–65 years | 395 | 30 | Reference | Reference | ||||
| >65 years | 231 | 23 | 1.29 | 1.09–1.52 | 0.002 | 1.31 | 1.10–1.55 | 0.002 |
| Residential location | ||||||||
| Bellarine Peninsula | 113 | 21 | 1.20 | 0.97–1.50 | 0.10 | 1.26 | 1.01–1.58 | 0.04 |
| Mornington Peninsula | 198 | 29.5 | 1.07 | 0.89–1.28 | 0.48 | 1.06 | 0.88–1.28 | 0.53 |
| South-East Bayside | 52 | 19 | 1.40 | 1.04–1.88 | 0.03 | 1.44 | 1.06–1.95 | 0.02 |
| Frankston area | 58 | 30 | 0.88 | 0.66–1.17 | 0.38 | 0.87 | 0.65–1.17 | 0.36 |
| Other (non-endemic) | 282 | 30 | Reference | Reference | ||||
| Lesion location | ||||||||
| Upper limb | 167 | 30 | Reference | |||||
| Lower limb | 425 | 30 | 1.04 | 0.87–1.24 | 0.69 | |||
| Other * | 91 | 21 | 1.16 | 0.89–1.49 | 0.27 | |||
| Manifestation | ||||||||
| Ulcer | 549 | 30 | Reference | Reference | ||||
| Non-ulcer † | 138 | 21 | 1.28 | 1.06–1.54 | 0.01 | 1.27 | 1.05–1.53 | 0.02 |
| Year of notification | ||||||||
| Increasing from 2011 | 703 | - | 0.97 | 0.93–1.00 | 0.06 | |||
| WHO lesion category | ||||||||
| I | 539 | 30 | 1.07 | 0.85–1.33 | 0.57 | |||
| II | 91 | 28 | Reference | |||||
| III | 55 | 28 | 1.30 | 0.93–1.81 | 0.13 | |||
* includes lesions on areas of the body other than limbs, and lesions in multiple locations (including limbs). † includes all non-ulcerative Buruli ulcer manifestations. HR = hazard rate CI = confidence interval. Bold type indicates significance for inclusion in the full and main effects models.