Table 3.

Associations between independent variables and diagnosis delay on univariate and multivariate Cox’s regression analysis.

	Observations	Median Delay (days)	Univariate			Multivariate
			Crude HR	95% CI	P-Value	Adjusted HR	95% CI	P-Value
Sex
Female	305	14	0.89	0.77–1.04	0.14
Male	398	7	Reference
Age group
<15 years	77	19	0.84	0.66–1.08	0.17
15–65 years	395	13	Reference
>65 years	231	7	1.08	0.92–1.28	0.33
Residential location
Bellarine Peninsula	113	0	2.63	2.09–3.30	<0.001	3.18	2.47–4.09	<0.001
Mornington Peninsula	198	0	1.97	1.63–2.37	<0.001	1.94	1.60–2.35	<0.001
South-East Bayside	52	20.5	1.04	0.77–1.39	0.82	1.07	0.79–1.44	0.67
Frankston area	58	16	1.17	0.88–1.55	0.28	1.21	0.91–1.61	0.19
Other (non-endemic)	282	29	Reference			Reference
Lesion location
Upper limb	167	12	Reference
Lower limb	425	13	1.02	0.85–1.22	0.823
Other *	91	6	1.14	0.88–1.47	0.32
Manifestation
Ulcer	549	10	Reference
Non-ulcer †	138	13.5	0.95	0.79–1.15	0.60
Year of notification
Increasing from 2011	703	-	1.03	0.99–1.06	0.19	1.09	1.04–1.13	<0.001
WHO lesion category
I	539	9	1.26	1.01–1.58	0.04
II	91	19	Reference
III	55	31	0.87	0.62–1.22	0.41

* includes lesions on areas of the body other than limbs, and lesions in multiple locations (including limbs). † includes all non-ulcerative Buruli ulcer manifestations. HR = hazard rate CI = confidence interval. Bold type indicates significance for inclusion in the full and main effects models.