Table A4.
Clinical pathology evaluated by relative mean values (%) obtained in the leukogram of animals vaccinated with vaccines against BVDV and BHV-1 with different commercial formulations.
| Variables | First Dose | Second Dose | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Vaccine A 2 | Vaccine B 3 | Vaccine C 4 | Control 5 | Vaccine A 2 | Vaccine B 3 | Vaccine C 4 | Control 5 | ||
| LYMPH 6(%) | 6 h1 | 46.33 a | 41.70 a | 42.00 a,b | 50.33 a,b,c | 51.78 A,b,a | 44.70 B,C,a | 36.70 C,a | 55.33 A |
| 24 h | 56.56 A,a,b | 49.30 B,a,b | 39.50 C,a | 44.17 B,C,a | 61.44 A,a,b | 56.10 A,b,c | 41.20 B,a,b | 57.33 A | |
| 48 h | 57.22 a,b | 54.20 b | 52.30 c | 56.00 b,c | 59.44 a,b | 52.90 a,b,c | 49.40 b,c | 59.00 | |
| 72 h | 58.56 b | 55.90 b | 50.80 b,c | 57.33 b,c | 61.11 a,b | 57.20 c | 51.70 c | 56.67 | |
| 168 h | 56.00 a,b | 56.40 b | 53.60 c | 55.67 a,b | 63.33 b | 55.30 c | 58.90 c | 63.17 | |
| MONO 7(%) | 6 h | 12.44 A,B,a,b | 10.30 A,a | 11.20 A,a,b | 15.83 C,a,b | 9.22 | 8.70 | 8.70 | 11.33 |
| 24 h | 13.89 A,B,C,a | 13.80 A,B,C,b | 13.00 A,B,C,a | 16.67 C,b | 7.33 | 9.90 | 7.70 | 8.00 | |
| 48 h | 12.44 a,b | 11.50 a,b | 11.80 a,b | 12.33 a,c,d | 9.56 | 10.30 | 8.60 | 9.67 | |
| 72 h | 13.22 A,a,b | 9.40 B,a | 11.00 A,B,a,b | 10.17 A,B,c,d | 9.78 | 9.90 | 10.90 | 9.67 | |
| 168 h | 9.67 b | 10.90 a,b | 9.40 b | 9.67 d | 8.78 | 9.80 | 9.30 | 8.00 | |
| BAS 8(%) | 6 h | 0.56 a | 0.50 | 0.40 | 0.67 | 0.45 A,a | 0.50 A,B,a | 0.30 A,B,a | 0.83 B,ª |
| 24 h | 1.11 b | 0.90 | 0.50 | 0.61 | 0.67 A,a,b | 0.70 A,a | 0.60 A,a | 1.67 B,ª | |
| 48 h | 0.37 a | 0.80 | 0.30 | 0.83 | 0.44 A,a | 1.80 B,b | 1.50 B,b | 1.00 A,B,a | |
| 72 h | 0.67 a | 0.90 | 0.70 | 0.67 | 1.33 b | 0.70 a | 1.00 a,b | 1.50ª | |
| 168 h | 0.67 a | 0.60 | 0.30 | 0.96 | 0.44 A,a | 1.10 A,B,a,b | 0.70 A,B,a | 1.50 B,a | |
| NEUTR 9(%) | 6 h | 36.80 A,a | 42.81 A,a | 43.40 A,a | 25.00 B | 35.00 B,a,b | 41.36 A,B,a | 49.50 A,a | 25.33 C |
| 24 h | 23.80 B,c,d,e | 30.00 B,b | 42.70 A,a | 27.00 B | 21.70 B,c,d,e | 27.81 B,b | 41.30 A,a | 23.67 B | |
| 48 h | 27.00 a,b,c,d | 26.00 b | 26.90 b | 22.67 | 22.40 c,d,e | 27.18 b | 30.90 b | 25.00 A | |
| 72 h | 25.70 A,B,b,c | 26.00 A,B,b | 31.90 A,b | 21.17 B | 20.10 e | 25.54 b | 29.40 b | 24.33 | |
| 168 h | 30.20 a,b,c | 26.18 b | 31.60 b | 29.16 | 21.30 B,d,e | 29.00 A,b | 25.20 A,B,b | 21.66 B | |
| EOS 10(%) | 6 h | 3.30 B,b,c | 3.54 B,c | 2.90 B,b | 8.78 A,a,b,c | 5.10 B,a,b,c | 4.81 B,b,c | 5.00 B,a,b | 7.16 A,a,b,c |
| 24 h | 5.00 B,a,b,c | 5.45 B,a,b,c | 4.70 B,a,b | 9.96 A,a,b | 8.20 a,b | 7.64 a,b | 9.10 a | 9.33 a,b,c | |
| 48 h | 3.30 b,c | 5.82 a,b,c | 8.20 a | 8.16 a,b,c | 8.70 A,a | 8.36 A,a | 9.40 A,a | 5.33 B,A,c | |
| 72 h | 2.20 B,c | 5.55 B,a,b,c | 5.50 B,a,b | 10.12 A,a | 8.30 a | 8.09 a,b | 7.10 a,b | 7.83 a,b,c | |
| 168 h | 3.10 c | 5.09 a,b,c | 5.50 a,b | 5.30 A,c | 7.00 A,a,b,c | 5.91 B,a,b,c | 5.80 B,a,b | 5.67 B,b,c | |
1 h: hours; 2 Vaccine A (n = 9); 3 Vaccine B (n = 10); 4 Vaccine C (n = 10); 5 Control (n = 6); 6 LYMPH: Lymphocytes; 7 MONO: Monocytes; 8 BAS basophils; 9 NEUTR: Neutrophils; 10 EOS: Eosinophils; capital letters on the same line show difference between treatments; lowercase letters in the same column show difference between times. Differences were considered significant when p ≤ 0.05.