Table 2.
Pharmacokinetic parameters of plasma meloxicam in oral- and subcutaneously-treated cows.
| MOS 1 | MET 2 | |||
|---|---|---|---|---|
| Mean (SE 9) | Range | Mean (SE) | Range | |
| Half Life 3 | 25.71 a (1.39) | 18.57–32.68 | 8.95 b (1.85) | 4.11–12.37 |
| AUC0-t4 | 67.46 a (14.25) | 25.52–113.26 | 22.26 b (4.70) | 14.84–45.04 |
| AUC0-∞5 | 86.13 a (17.46) | 39.89–150.05 | 25.53 b (5.11) | 15.31–46.65 |
| Cmax6 | 1.68 a (0.20) | 1.08–2.30 | 1.22 a (0.10) | 0.76–1.47 |
| Tmax7 | 13.33 a (3.37) | 8–24 | 5.33 b (0.42) | 4–6 |
| KE 8 | 0.03 a (0.001) | 0.02–0.04 | 0.09 b (0.02) | 0.05–0.17 |
1 Meloxicam Oral Solution; 2 Metacam; 3 hours (h); 4 area under the curve from 0 to last time (h * µg/mL); 5 area under the curve from 0 to infinity; 6 maximum plasma concentration (µg/mL); 7 time at maximum plasma concentration (h); 8 elimination rate constant (1/h), 9 standard error. a,b Rows with means of different superscripts are significantly different (p < 0.05).