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Models of HCMV entry into human cells using the trimer complex (TC) or PC complexes. The TC interacts with PDGFRα via gO, then gH/gL/gO activates the fusogenic activity of gB at the plasma membrane of human fibroblasts. Conversely, the PC first binds Nrp2, then the gH/gL component of the PC (or gH/gL/gO) induces endocytosis of virus particles [71], which are released into cytoplasm from endosomal membranes, following low-pH-induced activation of the gB fusion machinery (from [72]).
