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. 2019 Sep 12;7(3):112. doi: 10.3390/vaccines7030112

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The mutant viruses replicate less efficiently in the brain of infected animals. Viral genome copy number (A) and infectious virus titer (B) in the brain of animals infected with rMR (n = 6), m2MR (n = 6), and m5MR (n = 6) viruses at 6 dpi. Infectious virus titers from the spleen (C) and liver (D) of the animals. Unpaired Student’s t-test (two-tailed) was used to determine significance between the groups. ****, p < 0.0001; **, p < 0.01. (E) Hematoxylin and eosin staining of sections of the cerebrum of animals inoculated with PBS, or infected with rMR, m2MR, or m5MR viruses. Representative images of the cerebrum (40x) from animals in each group are shown. Prominent perivascular cuffing in rMR- and m2MR-infected samples are shown with white arrows. Scale bar (at bottom left), 60 µm.