Figure 5.

Mutant virus-infected animals are protected from lethal challenge. (A) Clinical scores, (B) weight loss, and (C) survival of the animals injected with PBS (n = 6), or infected with m2MR (n = 5), m5MR (n = 6), and after 28 days, challenged s.c. with 10,000 PFU rMR virus. (D) rMR viremia in the plasma following challenge. The horizontal dashed line shows the limit of detection. Unpaired Student’s t-test (two-tailed) for panel A was used to determine significance. ****, p < 0.0001; **, p < 0.01.