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. 2019 Aug 23;7(3):96. doi: 10.3390/vaccines7030096

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Zika virus neutralizing antibody titers after vaccination of IFNAR1^-/- mice with the sr-prM-E mRNA vaccine. Mice were intradermally electroporated on day 0 and 14 with 1 μg of sr-prM-E-mRNA ZIKV vaccine or sr-LUC-mRNA and two weeks after the boost, ZIKV-specific neutralizing antibody titers were determined by a neutralization test (NT). The neutralizing antibody titers are expressed as the reciprocal of the endpoint serum dilution that neutralized the challenge virus by (a) 50% (NT₅₀) or (b) 90% (NT₉₀). The lower limit of NT quantification was 20 and is represented by the dashed line (n = 5 sr-prM-E-mRNA group and n = 4 sr-LUC-mRNA group).