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Immunogenicity of the compounds. (a) The provoked immune response was characterized in a T-cell proliferation assay, and (b) the cytokine response was measured by using a LEGENDplex bead-based immunoassay. Data represented as mean ± SEM are percent population of proliferated splenocytes (a) and pg/mL amount of cytokines (b) (n = 3 mice/group). (***: p < 0.001; TNF-α and IL-6: not significant).
