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. 2019 Jul 8;7(3):61. doi: 10.3390/vaccines7030061

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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HAI antibody immune responses in immunized ferrets measured against a panel of viruses. (A) H5 NP/MDV LAIV. (B) H8 NP/MDV LAIV. (C) H9 NP/MDV LAIV. (D) A/herring gull/Sarma/51/2006 (H6N1) wild-type virus. (E) cH11/1N1 LAIV virus bearing chimeric HA gene (the HA stalk domain of Cal09 and the HA head domain of A/northern shoveler/Netherlands/18/99 (H11N9)) and the NA gene of Cal09. (F) A/South Africa/3626/2013 (pH1N1) wild-type virus. The HAI titers for H5 and H8 antigens were determined using horse red blood cells; the remaining antigens were tested with chicken RBCs. * indicates significant difference with the mock-vaccinated group. The dashed line indicates the limit of detection.