Table 1.
Contacting residues identified from the fitting of TfR into the 5 3D classes
| Location | Residue | No. 1 | No. 2 | No. 3 | No. 4 | No. 5 | Count |
| CPV chain-1 | |||||||
| BC loop (αBC: 86–91) | Met-87 | O | O | O | O | O | 5 |
| Asp-88 | O | O | 2 | ||||
| Ala-91 | O | O | O | O | O | 5 | |
| Val-92 | O | 1 | |||||
| EF loop (β’’EF:230–235) | Ser-226 | O | O | 2 | |||
| Gly-227 | O | O | O | O | 4 | ||
| Thr-228 | O | O | O | O | 4 | ||
| Pro-229 | O | O | O | O | 4 | ||
| Thr-230 | O | O | O | O | 4 | ||
| Asn-231 | O | O | O | O | O | 5 | |
| Ile-232 | O | O | O | O | O | 5 | |
| Tyr-233 | O | O | O | O | O | 5 | |
| His-234 | O | O | O | O | O | 5 | |
| Gly-235 | O | O | 2 | ||||
| CPV chain-2 | |||||||
| GH loop | Ala-300 | O | O | O | O | 4 | |
| Thr-301 | O | O | O | O | O | 5 | |
| Phe-303 | O | 1 | |||||
| No. of residues | 17 | 13 | 11 | 13 | 15 | 11 | |
| TfR | |||||||
| βI-1/βII-1 loop | Asn-205 | O | 1 | ||||
| Gln-207 | O | 1 | |||||
| βII-1 | Thr-209 | O | 1 | ||||
| Thr-211 | O | O | 2 | ||||
| Val-213 | O | O | O | O | O | 5 | |
| βII-1/βII-2 loop | Gly-214 | O | O | 2 | |||
| Met-215 | O | 1 | |||||
| Glu-216 | O | 1 | |||||
| Ser-217 | O | O | O | O | O | 5 | |
| Gly-218 | O | O | O | O | O | 5 | |
| Leu-219 | O | O | O | O | O | 5 | |
| Val-220 | O | O | O | O | O | 5 | |
| Tyr-221 | O | O | O | O | O | 5 | |
| βII-2 | Leu-222 | O | O | O | O | O | 5 |
| Glu-224 | O | O | 2 | ||||
| Ser-225 | O | O | 2 | ||||
| Glu-227 | O | 1 | |||||
| βII-3 | Thr-239 | O | O | 2 | |||
| βII-6/βII-7 loop | Gln-304 | O | O | O | 3 | ||
| βII-8 | Asn-382 | O | O | 2 | |||
| Lys-384 | O | O | 2 | ||||
| No. of residues | 21 | 10 | 9 | 9 | 18 | 12 |
The contacting residues on each surface (2 CPV chains and TfR) were listed and marked “O” for each class shown in Fig. 5. The residues were grouped for their secondary structures. Residues found in all 5 classes were denoted as “consistent” interactions and residues found in less than 5 classes were denoted as “variable” interactions.