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. 2019 Sep 9;6(3):94. doi: 10.3390/medicines6030094

Table 1.

Animal studies about the possible effect of functional foods and bioactive compounds on body weight control, obesity, and its metabolic consequences

Study Type
(Animals Used)
Number and Characteristics of Animals Functional Food/Dose/Duration Summary of Key Results Study Reference
Rats n = 10 Male rats per 4 groups
with obesity
Green tea
100 mg capsules or powder (catechins)
30 days
Reduced body weight gain Pan et al. 2016 [15]
Rats n = 35 male rats with high cholesterol, body weight, blood glucose, serum lipids Avocado
2 g avocado pulp
7 weeks
Increased cholesterol
Reduced body weight
Reduced blood glucose
Reduced BMI
Reduced serum lipids
Gupta et al. 2015 [17]
Rats n = 40 male rats with metabolic syndrome, cardiovascular, and hepatic structure Green coffee
68.3 mg/kg caffeine
8–9 weeks
Increased cardiovascular diseases Pauchal et al. 2012 [14]
Rats n = 80 rats (2 groups) with chronic diseases Berries
500 mg powder (anthocyanins)
7 weeks
Reduced chronic diseases Nohara et al. 2018 [19]
Mice acute n = 8–9 per group 149 g powdered berry
Colitis and T cell tumournecrosis, factor-α secretion
Inhibited colitis in mice and T cell tumor necrosis factor-α secretion Martin et al. 2018 [20]
Rats n = 40 male rats per 5 groups with diabetes mellitus Nuts (walnuts)
85.2 g
2 weeks
Reduced blood glucose levels Onwuli, et al. 2014 [21]
Rats n = 8 male rats per 5 groups with Type 2 diabetes mellitus, increased blood pressure Olive (oleuropein)
20–60 mg/day powder RCT
4 weeks, acute
Increased blood pressure, glucose Nekooeian et al. 2014 [16]
Dogs n = 6 dogs with gut health Pomegranate
50 mg powder
Positive impact on gut health Jose et al. 2017 [22]
Rats 5 groups Ginger
500 mg/kg, 30 days
Type 1 Diabetes mellitus
Increased liver weight
Decreased of plasma glucose levels
Abdulrazaq et al. 2011 [18]