Figure 2.

One well-supported molecular mechanism through which the human GAS5 lncRNA acquires a phenotype involves the folding of a small (49 nt) region common to multiple RNA isoforms into a stem-loop structure with high stability--where the stems create an RNA mimic (GRE, blue box) capable of competitive binding of the glucocorticoid receptor (a known DNA-binding protein). The colored RNA structure is drawn using the web-based server found at: http://rna.tbi.univie.ac.at/cgi-bin/RNAWebSuite/RNAfold.cgi The key guanine residue (G549) described by Hudson et al. [74] is indicated with a red arrow inside the blue box.