Figure 3.

Kino et al. [71] is the first publication describing the “ribo-repressor” element formed at the 3’ end of the human GAS5 lncRNA, present in all transcript isoforms, featuring five calculated hairpins (shown in purple). The minimal riborepressor (49 nt; shown in red above) is also depicted in a bioinformatically-calculated hairpin in Figure 2, essentially the hairpin 5 described by Kino et al. [71]. The folded RNA acts as a ribo mimic of the hormone response element in chromatin, termed “GREM” by Hudson et al. [74], who show that the riborepressor can bind the androgen, mineralocorticoid, and progesterone receptors in addition to the first-described glucocorticoid receptor.