Table 4.
Wolbachia strains of filarial nematodes of clinical relevance and ones used for antiwolbachial drug discovery.
| Filarial Nematode | Significance | Wolbachia | |||
|---|---|---|---|---|---|
| Strain | Super-group | Genome Size (Mb) * | Proteins * | ||
| Onchocerca volvulus | clinical | wOv | C | 0.96 | 649 |
| Onchocerca ochengi | advanced screen for drug and vaccine development [3,4] | wOo | C | 0.96 | 651 |
| Onchocerca gutturosa | in vitro screen for drug development [40,41] | wOg | C | – | – |
| Dirofilaria immitis | dog heartworm (veterinary) [42] | wDim | C | 0.92 | 823 |
| Wuchereria bancrofti | clinical | wWb | D | 1.06 (draft) | 961 (draft) |
| Brugia malayi | clinical; rodent efficacy model for drug and vaccine development [4] | wBm | D | 1.08 | 839 |
| Brugia timori | clinical | wBt | D | – | – |
| Brugia pahangi | rodent efficacy model for drug and vaccine development [17] | wBp | D | 1.4 (draft) | 803 (draft) |
| Litomosoides sigmodontis | rodent efficacy model for drug and vaccine development [17,18,43,44,45] | wLs | D | Data available, but not yet published ** | |
| Loa loa | clinical; microfilarial counter-screen for drug development [46] | – | – | – | – |
* Genome size and protein number were taken from the NCBI Genomes database for Wolbachia wOv [47] (BioProject PRJEB4840), wOo [48] (BioProject PRJEA81837), wWb [49] (BioProjects PRJNA388334), wBm [50] (BioProjects PRJNA12475), and wDim [42] and wBp [51] as published. ** http://nematodes.org/genomes/litomosoides_sigmodontis/