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. 2019 Sep 16;7(3):115. doi: 10.3390/vaccines7030115

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ELISPOT assays. (A) Splenocyte cells from immunized C57BL/6 were obtained on week four after immunization. IFN-gamma secretion was analyzed by ELISPOT assay. The number of IFN-gamma specific spots in the booster dose group was higher than for the single dose. (B) The number of IL-4-specific spots was similar to that for IFN-gamma. This indicates that the booster dose had a stronger effect than the single dose. The data was analyzed using the log-rank test (* P < 0.05; ** P < 0.01; and *** P < 0.001) and presented as mean ± SD. Error bars indicate standard deviations (SD).