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. 2019 Aug 22;7(3):95. doi: 10.3390/vaccines7030095

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Antibody levels in hamsters immunized with monosubunit vaccines or vaccines containing multiple subunits of recombinant factor H binding proteins (FHBPs). The vaccines were formulated with LMQ (a combination of neutral liposome, monophosphoryl lipid A, and Quillaja saponaria fraction 21). The antibody titers at one week after the third immunization were measured by enzyme-linked immunosorbent assay (ELISA). (A) Antibody titers after immunizations with individual recombinant proteins as mono-FHBP vaccine or pooled recombinant FHBPs as a multisubunit vaccine; (B) Isotyping of anti-LigAc, LenA, LcpA, and Lsa23 IgG subclasses. The specific antibody titers to tested antigens shown (as bars) were determined by subtracting the titers for nonspecific reactivity to recombinant 6× His tag non-FHBP (recombinant LipL32) and BSA from the total titers. The results are shown as mean ± SD. Mann–Whitney U test was used to compare antibody titer among vaccination groups; * represents p < 0.05.

Antibody levels in hamsters immunized with monosubunit vaccines or vaccines containing multiple subunits of recombinant factor H binding proteins (FHBPs). The vaccines were formulated with LMQ (a combination of neutral liposome, monophosphoryl lipid A, and Quillaja saponaria fraction 21). The antibody titers at one week after the third immunization were measured by enzyme-linked immunosorbent assay (ELISA). (A) Antibody titers after immunizations with individual recombinant proteins as mono-FHBP vaccine or pooled recombinant FHBPs as a multisubunit vaccine; (B) Isotyping of anti-LigAc, LenA, LcpA, and Lsa23 IgG subclasses. The specific antibody titers to tested antigens shown (as bars) were determined by subtracting the titers for nonspecific reactivity to recombinant 6× His tag non-FHBP (recombinant LipL32) and BSA from the total titers. The results are shown as mean ± SD. Mann–Whitney U test was used to compare antibody titer among vaccination groups; * represents p < 0.05.