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. 2019 Aug 22;7(3):95. doi: 10.3390/vaccines7030095

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Leptospiral load in kidneys of surviving hamsters immunized with mono-LigAc subunit vaccine or vaccines containing multiple subunits of recombinant factor H binding proteins (FHBPs). Total genomic DNA was extracted from kidneys and detected by qPCR. The cycle threshold of each sample was compared with leptospiral DNA standard curve to calculate bacterial burden which is expressed as bacterial DNA per milligram of tissue. The results are shown as mean of each vaccination group; HK = Heat-killed whole cell vaccine; LigAc = LigAc mono recombinant factor H binding protein (FHBP) and LMQ; 4Ags = multiple recombinant FHBPs (LigAc + LenA + LcpA + Lsa23) and LMQ. Only the HK, LigAc, 4Ags groups with at least 3 survivors were used for statistical analysis. Mann–Whitney U test was used to compare bacterial number among vaccination groups; * represents p < 0.05.