Fig. 1.

A whole-genome compendium of somatic mutations predominantly induced by UV light. (A) Whole genome somatic mutation data from 221 melanomas was initially assembled from earlier studies (16, 17) and a subset of 130 samples with high burden (≥10.000 mutations) and with a high fraction (≥80%) of mutations having characteristics of UV photoproduct formation (C > T in a dipyrimidine context or CC > TT) were included for further study. AMPG, Australian Melanoma Genome Project. (B) SNVs (n = 19.7 × 10⁶) in the final dataset are predominantly C > T. (C) Trinucleotide signature (genome normalized) for included SNVs show mutations primarily at dipyrimidines, characteristic of mutations arising from UV photoproduct formation.