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. 2019 Sep 23;116(41):20743–20749. doi: 10.1073/pnas.1908058116

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Copyright © 2019 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 2. — MET currents in OHCs of Tmc1 D569N; Tmc2^−/− and Tmc1 M412K; Tmc2^−/− mice. (A) Examples of maximal MET currents in apical OHCs of Tmc1^+/+, Tmc1 D569N/D569N, and Tmc1 M412K/M412K at P6. (B) Maximal MET currents in basal OHCs of Tmc1^+/+ and Tmc1 D569N/D569N and Tmc1 M412K/M412K at P5. At both cochlear locations, the maximal MET current is smaller in D569N. (C) Development of MET current (mean ± SEM) with postnatal age. Number of OHCs with points of increasing age—Tmc1^+/+Tmc2^−/−: base, open circles, 4, 5, 5, 4, 4, 3; Tmc1^+/+Tmc2^−/−: apex, open triangles, 3, 3, 3, 5, 7, 5, 6, 3; Tmc1 M412K/M412K; Tmc2^−/−: base, red circles, 3, 3, 4, 4, 5, 2; Tmc1 M412K/M412K; Tmc2^−/−: apex, red triangles, 2, 5, 11, 9, 10, 6; Tmc1 D569N/D569N; Tmc2^−/−: base, green circles, 2, 4, 5, 7, 4; and Tmc1 D569N/D569N; Tmc2^−/−: apex, blue triangles, 3, 3, 6, 9, 5.