Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 2;12(3):103. doi: 10.3390/ph12030103

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Scheme 1 — Reagents and conditions: (a) NaIO₄, THF (60 % aq. soln.), room temp., 2.5 h, 79% [19]; (b) NaBH₄, EtOH/H₂O, room temp., 1 h, 81% [19]; (c) theobromine, PPh₃, diethyl azodicarboxylate (DEAD), THF, 50 °C, 48 h, 16% or THF/DMF, MW, max. 150 W, 65 °C, 30 min, 44%; (d) adenine, PPh₃, DEAD, THF/DMF, MW, max. 150 W, 65 °C, 50 min, 31%; (e) 2-NHAc-6-Cl-purine, PPh₃, DEAD, THF, 50 °C, 16 h, 51%; (f) uracil, PPh₃, DEAD, THF, 50 °C, 18 h, 12% (6), 13% (7), 29% (8), 5% (9).